WEEK DATE |
TOPIC |
REQUIRED READING |
SUGGESTED READING |
| Click for ppt & pdfs Week 1A 1/24/12 |
Intro, phylogeny primer |
Delsuc et al. Nat Reviews Gen. 2005.Phylogenomics & the Reconstruction of the Tree of Life. |
Harrison & Langdale. A step by step guide to phylogeny reconstruction |
| Week 1B 1/26/12 |
Anatomy of a genome project | Metzker.Nat Reviews Gen.
2006.Sequencing technologies -
the next generation. |
|
| Week 2A 1/31/12 |
PAPER DISCUSSION | Clark et al. Nature. 2007. Evolution of genes and genomes on
the Drosophila phylogeny. |
|
| Week 2B 2/2/12 |
Orthology, paralogy, and gene history | Koonin.Annu Rev Gen. 2005. Orthologs, Paralogs, and Evolutionary Genomics | Thornton. 2004. Nat Reviews Gen. Resurrecting ancient genes: experimental analysis of extint molecules. |
| Brigham et al. 2006. Evolution of hormone-receptor complexity by molecular exploitation. |
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| Week 3A 2/7/12 |
Evolution of new gene functions | Zu & Wang. 2008; Lynch & Conery.Science 2000.The evolutionary fate and consequences of duplicate genes. |
Bailey & Eichler. Nat Reviews Gen. 2006.Primate segmental duplications: crucibles of evolution, diversity and disease |
| Week 3B 2/9/12 |
PAPER DISCUSSION |
Zhou et al. 2008. Genome Research. On the origin of new genes in Drosophila. |
Wu et al. 2011. PLoS Genetics. De novo origin of human protein-coding genes |
| Week 4A 2/14/12 |
Whole genome duplication (Dana Wohlbach, guest lecturer) | Semom & Wolfe.2007.Consequences of genome duplication. | Van de Peer.Nat. Reviews Gen. 2009.The evolutionary significance of ancient genome duplications. |
Week 4B 2/16/12 |
PAPER DISCUSSION | tbd | |
Week 5A 2/21/12 |
Horizontal Transfer & Bacterial Genomics |
Ochman et al. Nature 2000. Lateral gene transfer and the nature of bacterial innovation; Mira et al. Int Microbiol. 2010. The bacterial pan-genome: a new paradigm in microbiology. |
|
Week 5B 2/23/12 |
PAPER DISCUSSION | Smillie et al. Nature 2011. Ecology drives a global network of gene exchange connecting the human microbiome. |
|
Week 6A 2/28/12 |
Molecular evolution - Part I | Nielsen. Annu Rev Genet. 2005.Molecular signatures of natural selection. | M. Nei. 2005. Mol Biol. Evo. Selectionism and Neutralism in Molecular Evolution |
Week 6B 3/1/12 |
PAPER DISCUSSION | Fay, Wycoff, Wu.Nature. 2002. Testing the neutral theory of molecular evolution with genomic data from Drosophila. | |
| Gossman et al. Mol Biol Evol. 2010. Genome Wide Analyses Reveal Little Evidence for Adaptive Evolution in Many Plant Species |
Smith & Eyre-Walker.Nature. 2002.Adaptive protein evolution in Drosophila. | ||
| Week7A 3/6/12 |
Molecular evolution - Part II:genome-wide scans | Stinchcombe & Hoekstra.Heredity. 2007. Combining population genomics and quantitative genetics: finding the genes underlying ecologically important traits. Sabeti et al. 2002. Detecting recent positive selection in the human genome from haplotype structure |
|
Week 7B 3/8/12 |
PAPER DISCUSSION | Sabeti et al. 2007.Nature.Genome-wide detection and characterization of positive selection in human populations | |
| Week 8A 3/13/12 |
QTL mapping (Mike White, guest lecturer) | Broman 2001. Review of Statistical Methods for QTL mapping in experimental crosses. MacKay et al. 2009. The Genetics of Quantitive Traits: Challenges and Prospects. |
|
Week 8B 3/15/12 |
PAPER DISCUSSION | Colosimo et al. 2004. PLoS Biol. The genetic architecture of parallel armor plate reduction in threespine sticklebacks. Colosimo et al. 2005. Science. Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles |
Shapiro et al. 2009. Current Biol. The genetic architecture of skeletal convergence and sex determination in ninespine sticklebacks. |
Week 9A 3/20/12 |
Evolution of gene expression | Pall et al. Nat Gen Reviews 2006. An integrated view of protein evolution. Wray. 2007. Nat Gen Reviews. The evolutionary significance of cis-regulatory mutations. |
|
Week 9B 3/22/12 |
PAPER DISCUSSION |
Brawand et al. Nature 2011. The evolution of gene expression levels in mammalian organs. |
|
Week 10A 3/27/12 |
eQTL mapping & the cis-trans debate | Rockman & Kruglyak. Nat Reviews Gen 2006. Genetics of global gene expression. | Brem et al. Science. 2002Genetic dissection of transcriptional regulation in budding yeast. |
| Wittkopp et al. Nat Gen. 2008.Regulatory changes underlying expression differences within and between Drosophila species. | |||
| Week 10B 3/29/12 |
PAPER DISCUSSION | Tirosh et al. Science 2009 A yeast hybrid provides insight into the evolution of gene expression regulation. | |
| 4/2/12-4/6/12 Week 11A 4/10/12 |
Spring break - No Class Evolution of cis-regulatory motifs |
Ludwig et al. Nature 2000.Evidence for stabilizing selection in a eukaryotic enhancer element. |
|
Week 11B 4/12/12 |
PAPER DISCUSSION | tbd |
|
| Week 12A 4/17/12 |
Network evolution | Wohlbach et al. 2009. From elements to modules: regulatory evolution in Ascomycota fungi. Lavoie et al. 2010. PLoS Bio. Evolutionary tinkering with conserved components of a transcriptional regulatory network. |
Borneman et al. 2007. Science. Divergence of Transcription Factor Binding Sites Across Related Yeast Species. Kasowski et al. 2010. Science. Variation in Transcription Factor Binding Among Humans. |
Week 12B 4/19/12 |
PAPER DISCUSSION | Tsong Nature 2006. Evolution of alternative transcriptional circuits with identical logic. | Booth et al. Nature. 2010. Intercalation of a new tier of transcription regulation into an ancient circuit. |
| Week 13A 4/24/12 |
Evolutionary systems biology/ proteomics |
Yamada and Bork. Nat. Rev. 2009. Evolution of Biomolecular Networks - Lessons from Metabolic and Protein Interactions. |
|
Week 13B 4/26/12 |
PAPER DISCUSSION | Beltrao et al. 2009. PLoS Biology. Evolution of Phosphoregulation: Comparison of phosphorylation patterns across yeast species |
|
Week 14A 5/1/12 |
Final wrap-up, remaining questions |
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Week 14B 5/3/12 |
PAPER DISCUSSION | Clark et al. Nature. 2007. Evolution of genes and genomes on the Drosophila phylogeny. |
|
Week 15A 5/8/12 |
tbd | ||
Week 15B 5/10/12 |
tbd | ||